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This is for illnesses and diseases. For fungal infections, see fungal infections.

Illnesses, sometimes referred to as diseases, are negative status effects creatures can contract through various means.

Illness Onset status Method of contraction
glotrot sore throat drinking black ooze, or getting hit by a black jell on odd-numbered floors
ironshank stiff legs drinking black ooze, or getting hit by a black jell on even-numbered floors
monochrome blurry vision getting bitten by an adiyy

When infected, only symptoms, or the onset of that illness, will be visible at first. Unlike other status effects, instead of going away after a period of time, these statuses have a chance to get worse and progress into the disease proper. Once the creature is infected with the full disease, it will not disappear unless administered a cure that is randomly generated per game.

Differences between Fungal Infections

Despite the fact that itchy skin is classified as an illness-based effect, it does not use the same save type and thus honey, yuckwheat, and anything affecting disease saves will not affect it. A full on fungal infection is also not an illness and will only be affected by mechanics specific to fungal infections. For more information, see fungal infections.


Illnesses have little effect early on, but are able to progress into further stages with worse symptoms. To determine whether or not the disease will progress, a counter will start as soon as the creature is infected. Every day after initial symptoms, or 1,200 game ticks (a player turn with 100 quickness), the game will make a toughness saving throw of difficulty 13. If the successful saves compared to the number of failed saves is two or greater, the disease onset will cure itself without progressing. If the number of failed saves versus the amount of successful saves is greater than 3, or a total of 5 days (6,000 game ticks) have passed, the onset will progress into the full illness.

Increasing Save Chance

A +3 bonus can be added to the save by cooking a meal that has the effect "+3 to saves vs. disease", typically using either yuckwheat or honey. The Porridge is an accessible source of this effect. Drinking honey or eating a raw yuckwheat stem without cooking them will also grant a +2 save. Consuming both uncooked honey and a raw yuckwheat stem will confer no further bonuses other than the initial +2 bonus. However, the cooked meal save bonus and raw snack save bonus can stack for a total of +5.

Method Save Bonus New Save (base chance to succeed)
Eating a raw yuckwheat stem or drinking honey +2 11 (45%)
Eating a cooked meal that has +3 save vs diseases +3 10 (50%)
Eating a cooked meal and eating a raw yuckwheat stem/honey +5 8 (60%)

Curing Onset

Aside from succeeding saves, there are other ways of removing incubating illnesses. For player characters, while cooking with yuckwheat, there is a triggered effect where if successfully triggered, will cure an incubating disease at a 25% chance. With Carbide Chef, this can be combined with a simple trigger such as drinking water or setting oneself on fire.

Creatures with level 5 Regeneration or higher will also naturally cure themselves from all illnesses.

Curing diseases

For curing the full diseases, visit the specific pages.